Tavanta’s colorectal franchise is currently focused on anal fissure, a painful condition with a significant unmet medical need.

Overview of Anal Fissure
Current Treatments and Unmet Needs

1 Davids JS, Hawkins AT, Bhama, AR, et al. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Anal Fissures. Diseases of the Colon & Rectum. 2023; 66(2), 190–199.

2 Wald A, Bharucha AE, Limketkai B, et al. ACG Clinical Guidelines: Management of Benign Anorectal Disorders. Am J Gastroenterol. 2021;116(10):1987-2008.

3 RECTIV® (nitroglycerin) Ointment 0.4% – Prescribing Information: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021359s000lbl.pdf

4 Hyman NH, Cataldo PA. Nitroglycerin ointment for anal fissures: effective treatment or just a headache? Dis Colon Rectum. 1999;42(3):383-385.

5 Sellers S, Utian WH. Pharmacy compounding primer for physicians: prescriber beware. Drugs. 2012;72(16):2043-2050.

6 Shah M, Sandler L, Rai V, Sharma C, Raghavan L. Quality of compounded topical 2% diltiazem hydrochloride formulations for anal fissure. World J Gastroenterol. 2013;19(34):5645-50.

7 NORVASC® (amlodipine besylate) Tablets – Prescribing Information: https://labeling.pfizer.com/showlabeling.aspx?id=562